Critical Role of Novel O-GlcNAcylation of S550 and S551 on the p65 Subunit of NF-κB in Pancreatic Cancer

Critical Role of Novel O-GlcNAcylation of S550 and S551 on the p65 Subunit of NF-κB in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a mere 5-year survival of ~10%. This highlights the urgent need for innovative treatment options for PDAC patients. The nuclear factor κB (NF-κB) is a crucial transcription factor that is constitutively activated in...

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Bibliographic Details
Main Authors: Aishat Motolani, Matthew Martin, Benlian Wang, Guanglong Jiang, Faranak Alipourgivi, Xiumei Huang, Ahmad Safa, Yunlong Liu, Tao Lu
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
NF-κB
O-GlcNAcylation
pancreatic cancer
post-translational modification
Online Access:https://www.mdpi.com/2072-6694/15/19/4742

Internet

https://www.mdpi.com/2072-6694/15/19/4742

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