The structure of Leptospira interrogans GAPDH sheds light into an immunoevasion factor that can target the anaphylatoxin C5a of innate immunity

The structure of Leptospira interrogans GAPDH sheds light into an immunoevasion factor that can target the anaphylatoxin C5a of innate immunity

Leptospirosis is a neglected worldwide zoonosis involving farm animals and domestic pets caused by the Gram-negative spirochete Leptospira interrogans. This bacterium deploys a variety of immune evasive mechanisms, some of them targeted at the complement system of the host’s innate immunity. In this...

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Bibliographic Details
Main Authors: Sergio Navas-Yuste, Karla de la Paz, Javier Querol-García, Sara Gómez-Quevedo, Santiago Rodríguez de Córdoba, Francisco J. Fernández, M. Cristina Vega
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
structural biology
innate immunity
complement system
C5a anaphylatoxin
GAPDH – glyceraldehyde 3-phospate dehydrogenase
leptospirosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190943/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190943/full

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