Monoamine Oxidase-B Inhibitor Reduction in Pro-Inflammatory Cytokines Mediated by Inhibition of cAMP-PKA/EPAC Signaling

Monoamine Oxidase-B Inhibitor Reduction in Pro-Inflammatory Cytokines Mediated by Inhibition of cAMP-PKA/EPAC Signaling

Mucosal epithelial cell integrity is an important component of innate immunity and it protects the host from an environment rich in microorganisms. Virulence factors from Gram-negative bacteria [e.g. lipopolysaccharide (LPS)] induce significant pro-inflammatory cytokine expression. Monoamine oxidase...

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Bibliographic Details
Main Authors: Edward E. Putnins, Verena Goebeler, Mahyar Ostadkarampour
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
monoamine oxidases
monoamine oxidase inhibitors
lipopolysaccharide
inflammation
cytokines
cAMP
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.741460/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.741460/full

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