Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus

Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus

ABSTRACT NucS/EndoMS-dependent noncanonical mismatch repair (MMR) ensures the stability of genomic DNA in mycobacteria and acts as a guardian of the genome by preventing the accumulation of point mutations. In order to address whether the inactivation of noncanonical MMR could increase the acquisiti...

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Bibliographic Details
Main Authors: Rosilene Fressatti Cardoso, Isabel Martín-Blecua, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, José Ramón Valverde, Jesús Blázquez, Alfredo Castañeda-García
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium abscessus
drug resistance
antibiotic resistance
NucS
EndoMS
mutation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02228-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02228-22

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