Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice

Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice

Paclitaxel, a widely used cancer chemotherapeutic agent, has high incidence of neurotoxicity associated with the production of neuropathic pain, for which only duloxetine has shown significant but moderate analgesic effect. Since statins, classically used to reduce hypercholesterolemia, have shown a...

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Bibliographic Details
Main Authors: Nicolás Lobos, Sebastián Lux, Ramiro Javier Zepeda, Teresa Pelissier, José Luis Marcos, Gonzalo Bustos-Quevedo, Alejandro Hernández, Luis Constandil
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
rosuvastatin
duloxetine
paclitaxel
chronic pain
chemotherapy-induced neuropathy
isobolographic study
Online Access:https://www.mdpi.com/1422-0067/24/9/8359

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https://www.mdpi.com/1422-0067/24/9/8359

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