Altenusin, a fungal metabolite, alleviates TGF-β1-induced EMT in renal proximal tubular cells and renal fibrosis in unilateral ureteral obstruction

Altenusin, a fungal metabolite, alleviates TGF-β1-induced EMT in renal proximal tubular cells and renal fibrosis in unilateral ureteral obstruction

Renal fibrosis is a pathological feature of chronic kidney disease (CKD), progressing toward end-stage kidney disease (ESKD). The aim of this study is to investigate the therapeutic potential of altenusin, a farnesoid X receptor (FXR) agonist derived from fungi, on renal fibrosis. The effect of alte...

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Bibliographic Details
Main Authors: Natechanok Thipboonchoo, Somsak Fongsupa, Sanya Sureram, Suliporn Sa-nguansak, Chatchai Kesornpun, Prasat Kittakoop, Sunhapas Soodvilai
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Chronic kidney disease
fibrosis
Renal proximal tubular cell
TGF-β1/Smad
Unilateral ureteral obstruction
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024010144

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http://www.sciencedirect.com/science/article/pii/S2405844024010144

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