Angiogenic and Osteogenic Coupling Effects of Deferoxamine-Loaded Poly(lactide-co-glycolide)-Poly(ethylene glycol)-Poly(lactide-co-glycolide) Nanoparticles

Angiogenic and Osteogenic Coupling Effects of Deferoxamine-Loaded Poly(lactide-co-glycolide)-Poly(ethylene glycol)-Poly(lactide-co-glycolide) Nanoparticles

Angiogenesis and osteogenesis coupling processes are essential for bone regeneration, and human bone marrow stromal cells (hBMSCs) along with endothelial cells (ECs) are crucial participants. Deferoxamine (DFO), a hypoxia-mimetic agent, could activate the hypoxia-inducible factor (HIF)-1α signaling...

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Bibliographic Details
Main Authors: Manle Qiu, Chongyang Wang, Daoyun Chen, Chaoyong Shen, Huakun Zhao, Yaohua He
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Applied Sciences
Subjects:
PLGA-PEG-PLGA
nanoparticles
deferoxamine
drug delivery system
angiogenesis
osteogenesis
Online Access:http://www.mdpi.com/2076-3417/6/10/290

Internet

http://www.mdpi.com/2076-3417/6/10/290

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