Antioxidative NAC-Loaded Silk Nanoparticles with Opening Mucosal Tight Junctions for Nasal Drug Delivery: An In Vitro and In Vivo Study

Antioxidative NAC-Loaded Silk Nanoparticles with Opening Mucosal Tight Junctions for Nasal Drug Delivery: An In Vitro and In Vivo Study

Using nasal routes to deliver drugs to the brain using multifunctional nanoparticles (NPs) to bypass the blood–brain barrier (BBB) might enhance the delivery efficacy. Anti-oxidative N-Acetyl-L-cysteine (NAC)-loaded silk fibroin (SF/NAC) NPs are produced, characterized and studied as a potential del...

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Bibliographic Details
Main Authors: Tze-Wen Chung, Ting-Ya Wu, Zheng-Yu Siah, Der-Zen Liu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
SF/NAC NP
nasal NAC delivery
anti-oxidative
tight junction
mucosal cells
IVIS study
Online Access:https://www.mdpi.com/1999-4923/14/6/1288

Internet

https://www.mdpi.com/1999-4923/14/6/1288

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