The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples

The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples

Salivarian trypanosomes comprise a group of extracellular anthroponotic and zoonotic parasites. The only sustainable method for global control of these infection is through vaccination of livestock animals. Despite multiple reports describing promising laboratory results, no single field-applicable...

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Bibliographic Details
Main Authors: Stefan Magez, Zeng Li, Hang Thi Thu Nguyen, Joar Esteban Pinto Torres, Pieter Van Wielendaele, Magdalena Radwanska, Jakub Began, Sebastian Zoll, Yann G.-J. Sterckx
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pathogens
Subjects:
trypanosomosis
vaccination
enolase
ISG75
Online Access:https://www.mdpi.com/2076-0817/10/8/1050

Internet

https://www.mdpi.com/2076-0817/10/8/1050

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