Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy

Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy

Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunction in heterozygous (HET) Mybpc3c.772G>A knock-...

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Bibliographic Details
Main Authors: Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Hypertrophic cardiomyopathy
Sarcomere mutation
Metabolic health
Cardiac metabolism
Pathophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S277297612300020X

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http://www.sciencedirect.com/science/article/pii/S277297612300020X

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