The beneficial effect of probiotics in the prevention of irinotecan-induced diarrhea in colorectal cancer patients with colostomy: a pooled analysis of two probiotic trials (Probio-SK-003 and Probio-SK-005) led by Slovak Cooperative Oncology Group

The beneficial effect of probiotics in the prevention of irinotecan-induced diarrhea in colorectal cancer patients with colostomy: a pooled analysis of two probiotic trials (Probio-SK-003 and Probio-SK-005) led by Slovak Cooperative Oncology Group

BackgroundProbiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in...

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Bibliographic Details
Main Authors: Michal Mego, Barbora Kasperova, Jozef Chovanec, Radoslav Danis, Maria Reckova, Branislav Bystricky, Peter Konkolovsky, Silvia Jurisova, Stefan Porsok, Vladimir Vaclav, Maria Wagnerova, Marian Stresko, Bibiana Brezinova, Dagmar Sutekova, Sona Ciernikova, Daniela Svetlovska, Lubos Drgona
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Oncology
Subjects:
pooled analysis
irinotecan
diarrhea
probiotics
colorectal cancer
beta-glucuronidase
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1438657/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1438657/full

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