Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment

Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment

Abstract Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions. We hypothesised that cerebral hypoperfusion causes local hypoxia, affecting oligodendrocyte precursor cell—en...

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Bibliographic Details
Main Authors: Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. Backes, Robert J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn, Sébastien Foulquier
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Acta Neuropathologica Communications
Subjects:
Vascular dementia
Glial biology
OPC
Angiogenesis
BBB
cSVD
Online Access:https://doi.org/10.1186/s40478-023-01627-5

Internet

https://doi.org/10.1186/s40478-023-01627-5

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