Integrating single‐cell and spatial transcriptomes reveals COL4A1/2 facilitates the spatial organisation of stromal cells differentiation in breast phyllodes tumours

Integrating single‐cell and spatial transcriptomes reveals COL4A1/2 facilitates the spatial organisation of stromal cells differentiation in breast phyllodes tumours

Abstract Background Breast phyllodes tumours (PTs) are a unique type of fibroepithelial neoplasms with metastatic potential and recurrence tendency. However, the precise nature of heterogeneity in breast PTs remains poorly understood. This study aimed to elucidate the cell subpopulations composition...

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Bibliographic Details
Main Authors: Xia Li, Xuewen Yu, Jiaxin Bi, Xu Jiang, Lu Zhang, Zhixin Li, Mumin Shao
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Clinical and Translational Medicine
Subjects:
breast phyllodes tumour heterogeneity
fibroepithelial lesions
single‐cell RNA sequencing
spatial transcriptome
tumour grading
Online Access:https://doi.org/10.1002/ctm2.1611

Internet

https://doi.org/10.1002/ctm2.1611

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