Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells

Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells

Bcl-xL, a member of the Bcl-2 family, is a pro-survival protein involved in apoptosis regulation. We have previously reported the ability of Bcl-xL to form various types of fibers, from native to amyloid conformations. Here, we have mimicked the effect of apoptosis-induced caspase activity on Bcl-xL...

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Bibliographic Details
Main Authors: Alexis Gonneaud, Fatima-Zohra Fakhir, Emeline Landas, Enora Le Tallec, Elisabeth Chartier-Garcia, Christine Almunia, Alexandre Chenal, Vincent Forge, Christel Marquette
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
Bcl-xL
apoptosis
oxidative stress
amyloid fibers
Online Access:https://www.mdpi.com/1422-0067/21/20/7625

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https://www.mdpi.com/1422-0067/21/20/7625

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