Multi-Omics of Familial Thoracic Aortic Aneurysm and Dissection: Calcium Transport Impairment Predisposes Aortas to Dissection

Multi-Omics of Familial Thoracic Aortic Aneurysm and Dissection: Calcium Transport Impairment Predisposes Aortas to Dissection

Several genetic defects, including a mutation in myosin heavy chain 11 (<i>Myh11</i>), are reported to cause familial thoracic aortic aneurysm and dissection (FTAAD). We recently showed that mice lacking K1256 of Myh11 developed aortic dissection when stimulated with angiotensin II, desp...

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Bibliographic Details
Main Authors: Shota Tomida, Tamaki Ishima, Daigo Sawaki, Yasushi Imai, Ryozo Nagai, Kenichi Aizawa
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
multi-omics
familial thoracic aortic aneurysm and dissection
calcium transport
Online Access:https://www.mdpi.com/1422-0067/24/20/15213

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https://www.mdpi.com/1422-0067/24/20/15213

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