Examining Sodium and Potassium Channel Conductances Involved in Hyperexcitability of Chemotherapy-Induced Peripheral Neuropathy: A Mathematical and Cell Culture-Based Study

Examining Sodium and Potassium Channel Conductances Involved in Hyperexcitability of Chemotherapy-Induced Peripheral Neuropathy: A Mathematical and Cell Culture-Based Study

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, painful side effect which arises due to a number of chemotherapy agents. CIPN can have a prolonged effect on quality of life. Chemotherapy treatment is often reduced or stopped altogether because of the severe pain. Currently, there a...

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Bibliographic Details
Main Authors: Parul Verma, Muriel Eaton, Achim Kienle, Dietrich Flockerzi, Yang Yang, Doraiswami Ramkrishna
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Computational Neuroscience
Subjects:
chemotherapy-induced peripheral neuropathy
ion channel
bifurcation theory
hyperexcitability
paclitaxel
DRG neuron
Online Access:https://www.frontiersin.org/article/10.3389/fncom.2020.564980/full

Internet

https://www.frontiersin.org/article/10.3389/fncom.2020.564980/full

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