The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

<p>Abstract</p> <p>Fibroblasts derived from the progeroid Werner syndrome (WS) show reduced replicative lifespan and a “stressed” morphology, both phenotypes being alleviated by using the p38 MAP kinase inhibitor SB203580. Because p38 is a major hub for the control of stress-signal...

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Bibliographic Details
Main Authors: Davis Terence, Rokicki Michal J, Bagley Mark C, Kipling David
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Chemistry Central Journal
Subjects:
Werner syndrome
Senescence
p38
MAP kinase
MK2
MAPKAPK2
Stress
Ageing
Signalling
Online Access:http://journal.chemistrycentral.com/content/7/1/18

Internet

http://journal.chemistrycentral.com/content/7/1/18

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