MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5

MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5

The blood-tumor barrier (BTB) hinders delivery of chemotherapeutic drugs to tumors in the brain; previous studies have shown that the BTB can be selectively opened by endothelial monocyte activating polypeptide-II (EMAP-II), but the specific mechanism involved remains elusive. In this study, we foun...

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Bibliographic Details
Main Authors: Liangyu Chen, Yixue Xue, Jian Zheng, Xiaobai Liu, Jing Liu, Jiajia Chen, Zhen Li, Zhuo Xi, Hao Teng, Ping Wang, Libo Liu, Yunhui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
blood-tumor barrier
EMAP-II
miR-429
p70S6K
s6K
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00035/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00035/full

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