Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We show here that Notch3 inhibition in MM cells...

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Bibliographic Details
Main Authors: Hayley M. Sabol, Tânia Amorim, Cody Ashby, David Halladay, Judith Anderson, Meloney Cregor, Megan Sweet, Intawat Nookaew, Noriyoshi Kurihara, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Notch
Osteocytes
Myeloma
Cancer
Bone
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000148

Internet

http://www.sciencedirect.com/science/article/pii/S1476558622000148

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