Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection

Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection

Bloodstream infections induce considerable morbidity, high mortality, and represent a significant burden of cost in health care; however, our understanding of the immune response to bacteremia is incomplete. Langerin+ CD8α+ dendritic cells (DCs), residing in the marginal zone of the murine spleen, h...

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Bibliographic Details
Main Authors: Kelly A. Prendergast, Naomi J. Daniels, Troels R. Petersen, Ian F. Hermans, Joanna R. Kirman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
langerin
dendritic cell
diphtheria toxin
bacille Calmette–Guerin
systemic infection
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00953/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00953/full

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