Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited bioavailability due to extensive gastric and first-pass metabolism. To improve DUL's bioavailability; DUL-loaded e...

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Bibliographic Details
Main Authors: Radwa M.A. Abd-Elal, Aya M. Essawy, Maha A. Salem, Mahitab Elsayed, Mona G. Khalil, Eman Abdelhakeem, Nouran A. Ali, Mai Ahmed Tawfik
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Duloxetine hydrochloride
Elastosomes
Histopathology
Intranasal
In-vivo studies
Transdermal
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000385

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http://www.sciencedirect.com/science/article/pii/S2590156723000385

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