Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

Little is known about the early pathogenic events by which mutant superoxide dismutase 1 (SOD1) causes amyotrophic lateral sclerosis (ALS). This lack of mechanistic understanding is a major barrier to the development and evaluation of efficient therapies. Although protein aggregation is known to be...

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Bibliographic Details
Main Authors: René Günther, Arun Pal, Chloe Williams, Vitaly L. Zimyanin, Maria Liehr, Cläre von Neubeck, Mechthild Krause, Mrudula G. Parab, Susanne Petri, Norman Kalmbach, Stefan L. Marklund, Jared Sterneckert, Peter Munch Andersen, Florian Wegner, Jonathan D. Gilthorpe, Andreas Hermann
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
<i>SOD1</i>
ALS1
mitochondria
live cell imaging
axonal trafficking
Online Access:https://www.mdpi.com/2073-4409/11/7/1246

Internet

https://www.mdpi.com/2073-4409/11/7/1246

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