Evaluation of Pain Tolerance Threshold Following Administration of Anti-TNF-α in REM Sleep-deprived Male Wistar Rats

Evaluation of Pain Tolerance Threshold Following Administration of Anti-TNF-α in REM Sleep-deprived Male Wistar Rats

Background and Aim: The level of Tumor Necrosis Factor-alpha (TNF-α) changes by REM sleep deprivation. TNF-α is a known biomarker of REM sleep deprivation (RSD). Prior studies have shown that any alteration in REM sleep can increase the amount of TNF-α. Accordingly, the Pain Tolerance Threshold (PTT...

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Bibliographic Details
Main Authors: Mohammadjavad Hoseinpourfard, Mohammad Nasehi, Mohammad-Reza Zarrindast, Morteza Izadi, Mohammad Nami
Format: Article
Language:English
Published: Guilan University of Medical Sciences 2021-10-01
Series:Iranian Journal of Neurosurgery
Subjects:
pain
sleep
rem
immunity system
anti-tnf-α
hot-plate test
infliximab
Online Access:http://irjns.org/article-1-278-en.pdf

Internet

http://irjns.org/article-1-278-en.pdf

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