A Novel Family of Lysosomotropic Tetracyclic Compounds for Treating Leukemia

A Novel Family of Lysosomotropic Tetracyclic Compounds for Treating Leukemia

Acute myeloid leukemia (AML) is a heterogeneous hematological cancer characterized by poor prognosis and frequent relapses. Aside from specific mutation-related changes, in AML, the overall function of lysosomes and mitochondria is drastically altered to fulfill the elevated biomass and bioenergetic...

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Bibliographic Details
Main Authors: José M. Carbó, Josep M. Cornet-Masana, Laia Cuesta-Casanovas, Jennifer Delgado-Martínez, Antònia Banús-Mulet, Lise Clément-Demange, Carme Serra, Juanlo Catena, Amadeu Llebaria, Jordi Esteve, Ruth M. Risueño
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
leukemia
drug discovery
autophagy
apoptosis
new chemical entity
lysosome
Online Access:https://www.mdpi.com/2072-6694/15/6/1912

Internet

https://www.mdpi.com/2072-6694/15/6/1912

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