Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency

Background & Aims: The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are no targeted medications for the liver pathology with TJP2 deficiency. We leveraged...

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Bibliographic Details
Main Authors: Chao Zheng Li, Hiromi Ogawa, Soon Seng Ng, Xindi Chen, Eriko Kishimoto, Kokoro Sakabe, Aiko Fukami, Yueh-Chiang Hu, Christopher N. Mayhew, Jennifer Hellmann, Alexander Miethke, Nahrin L. Tasnova, Samuel J.I. Blackford, Zu Ming Tang, Adam M. Syanda, Liang Ma, Fang Xiao, Melissa Sambrotta, Oliver Tavabie, Filipa Soares, Oliver Baker, Davide Danovi, Hisamitsu Hayashi, Richard J. Thompson, S. Tamir Rashid, Akihiro Asai
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:JHEP Reports
Subjects:
PFIC (progressive familial intrahepatic cholestasis)
Cellular polarity
Bile acid transport
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922000180

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http://www.sciencedirect.com/science/article/pii/S2589555922000180

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