Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

High risk Neuroblastoma (NB) includes aggressive, metastatic solid tumors of childhood. The survival rate improved only modestly, despite the use of combination therapies including novel immunotherapies based on the antibody-mediated targeting of tumor-associated surface ligands. Treatment failures...

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Bibliographic Details
Main Authors: Alessandra Marrella, Alessandra Dondero, Maurizio Aiello, Beatrice Casu, Daniel Olive, Stefano Regis, Cristina Bottino, Daniela Pende, Raffaella Meazza, Guido Caluori, Roberta Castriconi, Silvia Scaglione
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
3D cancer model
neuroblastoma
NK cells
PVR
KIRS/HLA-I
PD-Ls
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01876/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01876/full

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