Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies
High risk Neuroblastoma (NB) includes aggressive, metastatic solid tumors of childhood. The survival rate improved only modestly, despite the use of combination therapies including novel immunotherapies based on the antibody-mediated targeting of tumor-associated surface ligands. Treatment failures...
Main Authors: | Alessandra Marrella, Alessandra Dondero, Maurizio Aiello, Beatrice Casu, Daniel Olive, Stefano Regis, Cristina Bottino, Daniela Pende, Raffaella Meazza, Guido Caluori, Roberta Castriconi, Silvia Scaglione |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-08-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01876/full |
Similar Items
-
Monocyte and Macrophage in Neuroblastoma: Blocking Their Pro-Tumoral Functions and Strengthening Their Crosstalk with Natural Killer Cells
by: Chiara Vitale, et al.
Published: (2023-03-01) -
Tumor Microenvironment and Hydrogel-Based 3D Cancer Models for In Vitro Testing Immunotherapies
by: Chiara Vitale, et al.
Published: (2022-02-01) -
B7-H3 in Pediatric Tumors: Far beyond Neuroblastoma
by: Cristina Bottino, et al.
Published: (2023-06-01) -
Strategies for Potentiating NK-Mediated Neuroblastoma Surveillance in Autologous or HLA-Haploidentical Hematopoietic Stem Cell Transplants
by: Cristina Bottino, et al.
Published: (2022-09-01) -
Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome
by: Elisa Brandetti, et al.
Published: (2021-08-01)