Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases. Yet, C1r-targeted therapeutic development is currently underrepresented relative to other complement targets....

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Bibliographic Details
Main Authors: Blake R. Rushing, Denise L. Rohlik, Sourav Roy, D. Andrew Skaff, Brandon L. Garcia
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
complement inhibitors
fragment-based drug discovery
surface plasmon resonance
Online Access:https://www.mdpi.com/1420-3049/25/17/4016

Internet

https://www.mdpi.com/1420-3049/25/17/4016

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