Skin Immuno-CometChip in 3D vs. 2D Cultures to Screen Topical Toxins and Skin-Specific Cytochrome Inducers

Skin Immuno-CometChip in 3D vs. 2D Cultures to Screen Topical Toxins and Skin-Specific Cytochrome Inducers

The targets of topical genotoxic agents are basal and stem cells of the skin. These cells may misrepair DNA lesions, resulting in deleterious mutations of tumor suppressors or oncogenes. However, the genotoxicity of many compounds has not as yet been determined and needs to be tested using a relevan...

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Bibliographic Details
Main Authors: Dean S. Rosenthal, Li-Wei Kuo, Sarah L. Seagrave, Vikas Soni, Nusrat Islam, Geetanjali Minsky, Lucia Dussan-Cuellar, Brian Ell, Cynthia M. Simbulan-Rosenthal, Peter Sykora
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Genes
Subjects:
genotoxicity
skin equivalents
integrin β1
cytochrome p450
Online Access:https://www.mdpi.com/2073-4425/14/3/630

Internet

https://www.mdpi.com/2073-4425/14/3/630

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