Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth

Abstract As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intracellular calcium homeostasis implicated in the occurrence of multiple types of diseases. Orai1 is the major player in mediating store-operated calcium entry (SOCE) and r...

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Bibliographic Details
Main Authors: Chunming Gu, Wenhao Zhang, Enze Yang, Congyou Gu, Zhaoyang Zhang, Jing Ke, Xiong Wang, Shengying Wu, Shan Li, Fuyun Wu
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00429-z