The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy

The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy

Perioperative neurocognitive disorders (PND) is a common postoperative neurological complication. Neuroinflammation is a major cause that leads to PND. Autophagy, an intracellular process of lysosomal degradation, plays an important role in the development and maintenance of nervous system. PK11195...

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Bibliographic Details
Main Authors: Nannan Lan, Yongxin Liu, Zhaodong Juan, Rui Zhang, Baoyu Ma, Keliang Xie, Lina Sun, Hao Feng, Meng Sun, Jianfeng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
lipopolysaccharide
autophagy
PK11195
perioperative neurocognitive disorders
translocator protein
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.615543/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.615543/full

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