Post‐transcriptional regulation of PIAS3 expression by miR‐18a in malignant mesothelioma

Protein inhibitor of activated STAT3 (PIAS3) is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper‐activated in various c...

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Bibliographic Details
Main Authors: Tian He, Karen McColl, Nneha Sakre, Yanwen Chen, Gary Wildey, Afshin Dowlati
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.12386