BRAF inhibition curtails IFN‐gamma‐inducible PD‐L1 expression and upregulates the immunoregulatory protein galectin‐1 in melanoma cells

BRAF inhibition curtails IFN‐gamma‐inducible PD‐L1 expression and upregulates the immunoregulatory protein galectin‐1 in melanoma cells

Although melanoma is considered one of the most immunogenic malignancies, spontaneous T‐cell responses to melanoma antigens are ineffective due to tumor cell‐intrinsic or microenvironment‐driven immune evasion mechanisms. For example, oncogenic BRAF V600E mutation in melanoma cells fosters tumor imm...

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Bibliographic Details
Main Authors: Patryk Górniak, Maja Wasylecka‐Juszczyńska, Iwona Ługowska, Piotr Rutkowski, Anna Polak, Maciej Szydłowski, Przemysław Juszczyński
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Oncology
Subjects:
BRAF mutations
Galectin‐1
immune escape
melanoma
PD‐L1
Online Access:https://doi.org/10.1002/1878-0261.12695

Internet

https://doi.org/10.1002/1878-0261.12695

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