Hypoxia-directed tumor targeting of CRISPR-Cas9 and HSV-TK suicide gene therapy using lipid nanoparticles

Hypoxia-directed tumor targeting of CRISPR-Cas9 and HSV-TK suicide gene therapy using lipid nanoparticles

Hypoxia is a characteristic feature of solid tumors that contributes to tumor aggressiveness and is associated with resistance to cancer therapy. The hypoxia inducible factor-1 (HIF-1) transcription factor complex mediates hypoxia-specific gene expression by binding to hypoxia-responsive element (HR...

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Bibliographic Details
Main Authors: Alicia Davis, Kevin V. Morris, Galina Shevchenko
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CRISPR-Cas9
HSV-tk
lipid nanoparticle
cancer
hypoxia
hypoxia regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000389

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http://www.sciencedirect.com/science/article/pii/S2329050122000389

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