Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.

Bibliographic Details
Main Authors: Huanzhen Ni, Marine Z. C. Hatit, Kun Zhao, David Loughrey, Melissa P. Lokugamage, Hannah E. Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32281-5

Internet

https://doi.org/10.1038/s41467-022-32281-5

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