Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.
Bibliographic Details
| Main Authors: |
Huanzhen Ni,
Marine Z. C. Hatit,
Kun Zhao,
David Loughrey,
Melissa P. Lokugamage,
Hannah E. Peck,
Ada Del Cid,
Abinaya Muralidharan,
YongTae Kim,
Philip J. Santangelo,
James E. Dahlman |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32281-5
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