GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation

GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation

The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset. Employing Gsdme- and apolipoprotein E-deficient (<i>Gsdme<sup>−/...

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Bibliographic Details
Main Authors: Shiyao Xie, Enyong Su, Xiaoyue Song, Junqiang Xue, Peng Yu, Baoli Zhang, Ming Liu, Hong Jiang
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
GSDME
atherosclerosis
vascular inflammation
endothelial cells
mitochondrial damage
STING pathway
Online Access:https://www.mdpi.com/2227-9059/11/9/2579

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https://www.mdpi.com/2227-9059/11/9/2579

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