Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection

Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection

ABSTRACT Chagas disease (CD), caused by Trypanosoma cruzi, affects approximately 6 to 7 million people in Latin America, with cardiomyopathy being the clinical manifestation most commonly associated with patient death during the acute phase. The etiological treatment of CD is restricted to benznidaz...

Full description

Bibliographic Details
Main Authors: Juliana Magalhães Chaves Barbosa, Yasmin Pedra Rezende, Tatiana Galvão de Melo, Gabriel de Oliveira, Cynthia Machado Cascabulho, Evelyn Nunes Goulart da Silva Pereira, Anissa Daliry, Kelly Salomão Salem
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
Trypanosoma cruzi
Chagas disease
amiodarone
benznidazole
cardiac function
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01852-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.01852-21

Similar Items