A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice

A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice

Abstract A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecular mechanism(s) underlying HFD-induced feeding pa...

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Bibliographic Details
Main Authors: Tsutomu Sasaki, Rika Numano, Hiromi Yokota-Hashimoto, Sho Matsui, Naobumi Kimura, Hideyuki Takeuchi, Tadahiro Kitamura
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Brain
Subjects:
Diet-induced obesity
Feeding clock
Feeding rhythm
Gap junction
Hyperphagia
Hypothalamic inflammation
Online Access:http://link.springer.com/article/10.1186/s13041-018-0372-9

Internet

http://link.springer.com/article/10.1186/s13041-018-0372-9

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