Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib.

Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib.

Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell com...

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Bibliographic Details
Main Authors: Jasmine Foo, Mark W Drummond, Bayard Clarkson, Tessa Holyoake, Franziska Michor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2730033?pdf=render

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http://europepmc.org/articles/PMC2730033?pdf=render

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