A sensitive and robust lc-ms/ms method with monolithic column and electrospray ionization for the quantitation of efavirenz in human plasma: application to a bioequivalence study

A sensitive and robust lc-ms/ms method with monolithic column and electrospray ionization for the quantitation of efavirenz in human plasma: application to a bioequivalence study

An LC-MS/MS method has been developed for the determination of efavirenz (EFZ) in human plasma using hydrochlorothiazide as internal standard (I.S.). An ESI negative mode with multiple reaction-monitoring was used monitoring the transitions m/z 313.88→69.24 (EFZ) and 296.02→204.76 (I.S.). Samples we...

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Bibliographic Details
Main Authors: Danilo Cesar Galindo Bedor, Jose Homero de Souza Filho, Virna Ligiane Souza Ramos, Talita Mota Gonçalves, Carlos Eduardo Miranda de Sousa, Davi Pereira de Santana
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2011-01-01
Series:Química Nova
Subjects:
efavirenz
bioequivalence
LC-MS/MS
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600007&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600007&lng=en&tlng=en

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