Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

ABSTRACT Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication organelles (ROs) consisting of modified endoplasmic...

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Bibliographic Details
Main Authors: Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mBio
Subjects:
convoluted membranes
electron tomography
membrane structure
nidoviruses
nonstructural proteins
replication complex
Online Access:https://journals.asm.org/doi/10.1128/mBio.01658-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01658-17

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