Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation

Summary: Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in the colonic lamina propria (cLP) and protect against nonintestinal inflammatory diseases, such as atherosclerosis and post-infarction myocardial...

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Bibliographic Details
Main Authors: Fen Yang, MD, Ni Xia, MD, PhD, Shuang Guo, MD, Jiyu Zhang, MS, Yuhan Liao, MS, Tingting Tang, MD, PhD, Shaofang Nie, MD, PhD, Min Zhang, MD, PhD, Bingjie Lv, MD, Yuzhi Lu, MD, PhD, Jiao Jiao, MD, PhD, Jingyong Li, MD, PhD, Weimin Wang, PhD, Desheng Hu, MD, PhD, Xiang Cheng, MD, PhD
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:JACC: Basic to Translational Science
Subjects:
abdominal aortic aneurysm
colonic regulatory T cell
propionate
recirculation
short-chain fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X2200184X

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http://www.sciencedirect.com/science/article/pii/S2452302X2200184X

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