Exploring the mechanism of sweetener neohesperidin dihydrochalcone on oral tolerance via a network pharmacology approach combined with vivo and vitro methods

Neohesperidin dihydrochalcone (NHDC) is a kind of sweetener widely used in food processing. Some artificial sweeteners induce food allergy by breaking oral tolerance (OT). The relationship between NHDC and oral tolerance are important in food safety. We explored the possible effects of NHDC on OT vi...

Full description

Bibliographic Details
Main Authors: Xiaolei Shi, JihaoWei, Yupu Zhang, Jingwen Xue, Yongri Jin, Xuwen Li
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622002547