Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress

Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress

Abstract Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons and has a poor prognosis. We focused on TAR DNA-binding protein 43 kDa (TDP-43), which is a common component of neuronal inclusions in many ALS patients. To analyze the contribution of TDP-43 mutations to ALS in hum...

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Bibliographic Details
Main Authors: Asako Onda-Ohto, Minami Hasegawa-Ogawa, Hiromasa Matsuno, Tomotaka Shiraishi, Keiko Bono, Hiromi Hiraki, Yumi Kanegae, Yasuyuki Iguchi, Hirotaka James Okano
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Brain
Subjects:
Amyotrophic lateral sclerosis
iPSC
Motor neuron
Oxidative stress
Online Access:https://doi.org/10.1186/s13041-023-01050-w

Internet

https://doi.org/10.1186/s13041-023-01050-w

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