Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.

Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.

Paclitaxel (Taxol)-induced cell death requires the intrinsic cell death pathway, but the specific participants and the precise mechanisms are poorly understood. Previous studies indicate that a BH3-only protein BIM (BCL-2 Interacting Mediator of cell death) plays a role in paclitaxel-induced apoptos...

Full description

Bibliographic Details
Main Authors: Anna V Miller, Mark A Hicks, Wataru Nakajima, Amanda C Richardson, Jolene J Windle, Hisashi Harada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3618047?pdf=render

Internet

http://europepmc.org/articles/PMC3618047?pdf=render

Similar Items