Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis

The Janus kinase 1/3 inhibitor tofacitinib has demonstrated an antipruritic effect in two phase III studies in psoriasis. However, the mechanisms behind this antipruritic effect are still unknown. We presently investigated whether tofacitinib affects spontaneous itch as well as expression of itch-re...

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Bibliographic Details
Main Authors: Takashi Hashimoto, Kent Sakai, Kristen M. Sanders, Gil Yosipovitch, Tasuku Akiyama
Format: Article
Language:English
Published: Medical Journals Sweden 2019-01-01
Series:Acta Dermato-Venereologica
Subjects:
Online Access: https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3086