SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter

SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter

Abstract Background SIRT6, an important NAD+‐dependent protein, protects endothelial cells from inflammatory and oxidative stress injuries. However, the role of SIRT6 in cardiac microvascular endothelial cells (CMECs) under ischemia‒reperfusion injury (IRI) remains unclear. Methods The HUVECs model...

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Bibliographic Details
Main Authors: Zhenyang Guo, Xueting Yu, Shuang Zhao, Xin Zhong, Dong Huang, Runyang Feng, Peng Li, Zheyan Fang, Yiqing Hu, Zhentao Zhang, Mukaddas Abdurahman, Lei Huang, Yun Zhao, Xiangdong Wang, Junbo Ge, Hua Li
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Clinical and Translational Medicine
Subjects:
endoplasmic reticulum stress
ischemia‒reperfusion injury
SIRT6
Online Access:https://doi.org/10.1002/ctm2.1377

Internet

https://doi.org/10.1002/ctm2.1377

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