Identification and Structural Characterization of Novel Chondroitin/Dermatan Sulfate Hexassacharide Domains in Human Decorin by Ion Mobility Tandem Mass Spectrometry

Identification and Structural Characterization of Novel Chondroitin/Dermatan Sulfate Hexassacharide Domains in Human Decorin by Ion Mobility Tandem Mass Spectrometry

Chondroitin sulfate (CS) and dermatan sulfate (DS) are found in nature linked to proteoglycans, most often as hybrid CS/DS chains. In the extracellular matrix, where they are highly expressed, CS/DS are involved in fundamental processes and various pathologies. The structural diversity of CS/DS doma...

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Bibliographic Details
Main Authors: Mirela Sarbu, Raluca Ica, Edie Sharon, David E. Clemmer, Alina D. Zamfir
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
chondroition/dermatan sulfate
human decorin
ion mobility mass spectrometry
tandem mass spectrometry
structural analysis
sulfation code
Online Access:https://www.mdpi.com/1420-3049/27/18/6026

Internet

https://www.mdpi.com/1420-3049/27/18/6026

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