Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Abstract Background RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity. Elp1 gene encodes IKAP/ELP1, a core subunit of the Elongator complex, which has been impl...

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Bibliographic Details
Main Authors: Wei-Ting Chen, Huan-Yi Tseng, Chung-Lin Jiang, Chih-Ying Lee, Peter Chi, Liuh-Yow Chen, Kai-Yin Lo, I-Ching Wang, Fu-Jung Lin
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Biomedical Science
Subjects:
Elp1
RAD51
Homologous recombination
DNA damage
Translational regulation
Online Access:https://doi.org/10.1186/s12929-021-00773-z

Internet

https://doi.org/10.1186/s12929-021-00773-z

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